Welcome to IOTA's blog: Window on Glioblastoma


The Glioblastoma Cell Culture Resource

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Executive summary
This article focusses on a collection of human glioblastoma cell lines that have been produced and examined in great detail by scientists and clinicians from Uppsala University and their collaborators. The cells are made available to the research community to facilitate our understanding of the basic mechanisms of disease as well as to identify targets for novel drugs.
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Glioblastoma: the endgame

Download this article as a pdf here.
SPACE
Executive summary
Understanding the cancer cell phenotype is central to both cancer diagnosis and treatment. Discrete molecular signatures among cancer phenotypes underpin patient stratification, while rapid methods for detailed phenotyping in the clinic (via liquid biopsies and tumour imaging) enable the delivery of personalised, effective precision medicines to the cancer patient. Here, briefly, we describe how emerging data are defining molecular phenotypes among specific cancer cell lineages, and how these can be used in phenotypic screening to discover and profile drugs which modulate them. We focus on recent advances in molecular phenotyping for human glioma and its high-grade counterpart, glioblastoma multiforme (GBM), and review how laboratory advances for glioma are translating to the clinic.
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