Welcome to IOTA's blog: Window on Glioblastoma


Hydroxyurea combined with temozolomide for treating glioblastoma

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SPACE
Executive summary
Although chemotherapy of brain tumours with temozolomide (TMZ) has improved glioblastoma patient survival compared with earlier therapies, the development of resistance to this drug is a major problem. This article describes the search for drugs that may overcome this resistance when used in combination with TMZ. Hydroxyurea was identified as such a drug and shown to significantly enhance the killing of a range of GBM cell types. The detailed findings are sufficiently encouraging to support an early clinical trial of hydroxyurea and temozolomide in patients.
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Liquid Biopsies for Early Cancer Detection

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SPACE
Executive summary
Early detection of many cancers is believed to save lives, which is why routine screening for breast and bowel cancer is available to those in the general population who are likely to benefit. This article by a large team of US scientists describes a recently published blood test for multiple cancer types, which while sophisticated, is relatively cheap and accurate. The article discusses some of the features of this test and whether it could one day be modified to screen people for early signs of brain cancer.
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